What are harm reduction strategies for people who use kratom or 7-OH?

There are several important harm reduction strategies for people who use products sold as kratom or 7-OH.

Never use alone.

People should avoid using kratom or 7-OH alone because these products can lead to adverse effects or an overdose. Kratom and 7-OH appear to respond to naloxone, the opioid overdose reversal medication. Make sure naloxone is available and give it to anyone who is overdosing.

Monitor breathing.

When responding to a kratom or 7-OH-involved overdose, make sure the person is breathing. Place them in the recovery position, so they do not hurt themselves.

If the person does not take at least 10 breaths a minute, call 911 for help and administer rescue breaths until help arrives.

Go slow.

People should “go slow” when using kratom or 7-OH by taking a little bit at a time to reduce the risk of adverse effects.

Don’t mix.

It is also advised that people do not take kratom or 7-OH in combination with opioids or depressant drugs, including alcohol. This can increase the risk of an overdose and other serious adverse effects.

Reviewed and updated by Dr. Sheila P. Vakharia on 04/01/2026.

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