What happens if you mix kratom or 7-OH with other drugs?

Using products sold as kratom or 7-OH alongside other drugs can be risky.

Almost all cases of kratom-involved fatalities or serious adverse effects reported in the U.S. have involved other drugs. The risk of overdose increases when these products are taken with opioids or sedative drugs. When taken with stimulants, they can increase the risk of cardiovascular or other health risks. Depending on the amount or combination of drugs, people can experience intense effects, toxicity, or even organ damage.

Even if people believe they are consuming a product containing only kratom or 7-OH, there is still a chance that these products could be adulterated or contaminated, have unknown chemical contents, or vary in potency from batch to batch. This is due to the lack of regulatory oversight for kratom and 7-OH product manufacturing, labeling, and quality control.

Reviewed and updated by Dr. Sheila P. Vakharia on 04/01/2026.

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